COMPARISON TO OTHER SQ IMPLANTS
The main difference between our technologies and other available implant delivery systems is the ability to achieve zero order release pharmacokinetics (i.e., maintain a constant rate of drug output over time) through passive (non-mechanical) diffusion.
One example of an active delivery implant system is the Duros® technology which uses an osmotic pump (moving piston) to enable sustained drug release. Compared to active (mechanical) systems, Delpor’s technologies offer several benefits including:
- Reduced complexity in both manufacturing and operation
- Enhanced capacity (more than 2 times higher) due to hollow internal structure (most osmotic systems use over 50% of the internal volume for the osmotic engine). This allows us to make the implant much smaller or make it last twice as long.
- Ability to deliver drugs that are not soluble (i.e., use the drug in powder form not just in solution or suspension)
- Lower cost of manufacturing
The ability to deliver sustained zero order release through passive (non-mechanical) diffusion overcomes several challenges and creates the potential for several promising products.